Original scientific paper
Whole Saliva Levels of Some Inflammatory Mediators in Patients with Previous Evidence of Periodontitis: a Pilot Study
Andrija Bošnjak
; Meniga & Bošnjak, LLC, Zagreb, Croatia, University of Rijeka, School of Medicine, Department of Oral diseases and Periodontology, Rijeka, Croatia
Vanja Vučićević-Boras
; University of Zagreb, School of Dental Medicine, Department of Oral Medicine, Zagreb, Croatia,
Josip Lukač
; Sisters of Mercy Clinical Hospital, Department of Oncology and Nuclear Medicine, Zagreb, Croatia
Suzana Brozović
; University of Louisville, Department of Pediatrics, Louisville, Kentucky, USA
Abstract
Purpose: Little is known on levels of inflammatory mediators in saliva in periodontitis-affected individuals. Material and Methods: In order to establish the pattern of their concentrations in different stages of periodontal healing process, we have measured the levels of alkaline phosphatase (ALP), lactoferrin (LF), myeloperoxidase (MPO), interleukin-1 (IL-1), and GRO-α in patients with previous periodontal disease. Whole saliva samples were collected immediately following, as well as eight weeks after periodontal treatment in a group of 16 subjects with clinical signs and symptoms of periodontitis. Results: Statistical analysis revealed significant differences of clinical periodontal parameters and in levels of mediators between two measurements. Concentrations of CRP, LF, GRO, MPO, IL-1 and ALP decreased with periodontal healing, while the concentration of β2-MG was increased. Conclusion: It may be concluded that cytokine concentrations are possible risk indicators for active periodontal disease.
Keywords
Periodontitis; Saliva; Alkaline Phosphatase; Lactoferrin; Peroxidase; Interleukin-1; Enzyme-Linked Immunosorbent Assay; Citokines
Hrčak ID:
34355
URI
Publication date:
15.3.2009.
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