Review article

Validation of Analytical Methods and Laboratory Procedures for Chemical Measurements

Piet van Zonen
Henk A. van'T Klooster
Ronald Hoogerbrugge
Steven M. Gort
Henk J. van de Wiel

Abstract

Method validation is a key element in the establishment of reference methods and in the assessment of a laboratory’s competence in producing reliable analytical data. Hence, the scope of the term »method validation« is wide, especially if one bears in mind the role of Quality Assurance/Quality Control (QA/QC). The paper puts validation in the context of the process generating chemical information, introduces basic performance parameters included in the validation processes, and evaluates current approaches to the problem.
Two cases are presented in more detail: the development of European standard for chlorophenols and its validation by a full scale collaborative trial and the intralaboratory validation of a method for ethylenethiourea (ETU) by using alternative analytical techniques.

Keywords

analytical methods; chemical measurements; laboratory procedures; method validation; quality assurance; proficiency testing; reference materials; standardisation; validation

Hrčak ID:

3272

URI

https://hrcak.srce.hr/3272

Publication date:

13.5.1999.

Article data in other languages: croatian

Visits: 17.464 *