Original scientific paper

ACQUIRED GENETIC CHANGES IN SECONDARY TUMOR DISEASES

Iskra Petković ; Klinika za dječje bolesti Zagreb, Medicinski fakultet Sveučilišta u Zagrebu, Zagreb

Abstract

Recent years have seen significant progress in the treatment of patients with malignancies, but have increased the risk of late complications including secondary cancers. Frequent complications are therapy related myelodysplastic syndrome (tMDS) and acute myeloid leukaemia (tAML). This article reviews the results published so far of genetic investigations of patients with tMDS and tAML. The review focuses on acquired genetic changes, specific clonal chromosomal aberrations, gene mutations, current knowledge of the relationship between cytotoxic agents used in previous treatment with genome abnormalities, and classification of tMDS/tAML according to genetic and clinical characteristics. The available results indicate that cytogenetic and molecular analysis have clinical usefulness in the diagnosis and management of patients with tMDS/tAMl, they contribute to the understanding of leukemogenesis and the role of cytotoxic agents in the etiology of acute leukaemia.

Keywords

Descriptors: NEOPLASMS, SECOND PRIMARY – etiology, genetics; LEUKEMIA, MYELOID, ACUTE - etiology, genetics; MYELODYSPLASTIC SYNDROMES - etiology, genetics; ANTINEOPLASTIC AGENTS – adverse effects; CHROMOSOME ABERRATIONS

Hrčak ID:

34968

URI

https://hrcak.srce.hr/34968

Publication date:

9.3.2009.

Article data in other languages: croatian

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