Professional paper

Laboratory test values as proof of hipersensitivity in patients with positive dermatological test on home dust and house dust mites

Nataša Skitarelić ; General Hospital Zadar, Department for pediatry
Joško Mišulić ; General Hospital Zadar, department for pediatry, Zadar, Croatia
Neven Skitarelić ; General Hospital Zadar, Department for Otorhinolaryngology, Zadar, Croatia
Ana Vuletić ; General Hospital Zadar, Department for medical biochemistry, Zadar, Croatia
Vanja Troskot ; General Hospital Zadar, department for pediatry, Zadar, Croatia

Abstract

Introduction: Allergies are on the rise today. Besides the fact that allergy tests are present in daily practice, allergy diagnosis is still complicated considering that there is no unique and exact test for
hipersensitivity proof. The aim of our work is to test the values of daily laboratory diagnostics tests on a group of children with hipersensitivity to house dust.
Patients and Methods: A prospective test was performed in the Child Health Protection Department of Zadar General Hospital which consisted of 64 children suffering from asthma and other allergy diseases with hypersensitivity in prick test on house dust and maggots. A detailed family and personal history was taken from all the children, clinical exam performed, objective lung spirometry measurement in children older than 7 and skin testing. All examinees were tested by the method of pricking the volar part of the forearm with allergen drops. Total and specific IgE antibodies were stablished, the number of eosinophilic granulocytes in peripheral blood, Dunger test, cytological swabs of the nose mucuous membrane and serum
eosinophile catheon protein. Statistical data processing was erformed on a PC, and the values P < 0.01 were considered statistically significant.
Results: The sick children were from 4 to 15 years of age: among the 64 children 39 (61%) were of male gender, while 25 children (39%) were of female gender. The family history was positive on allergies with 28 (44%) of the sick children. Besides house dust and maggots, 24 of the 64 (37%) patients proved hipersensitive to one or more pollen allergens. Most of the patients had clinical symptoms of rhinitis or rhinitis combined with conjunctivitis.
Most of the afflicted children live in an urban environment. An increased number of eosinophiles in the cytological swap of nose mucuous, ImmunoCAP Total IgE and UniCAP test, P < 0.01 were statistically significant proof of hipersensitivity to house dust and maggots with afflicted children.
Conclusion: Three out of six laboratory tests of the skin have shown high particularity in confirming allergy with patients that are hypersensitive to house dust. All three aforesaid tests are inevitable in the daily work with atopists.

Keywords

atopy; laboratory tests; house dust

Hrčak ID:

37769

URI

https://hrcak.srce.hr/37769

Publication date:

1.6.2009.

Article data in other languages: croatian

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