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Periodicum biologorum, Vol. 111 No. 2, 2009.

Other

Vasoactive stress hormone (adrenaline, noradrenaline and cortisol) concentration in plasma after administration of low doses of S-(+)-ketamine epidurally

SLOBODAN MIHALJEVIĆ ; Clinic of Gynecology and Obstetrics, Department for Anaesthesiology, CHC Zagreb, Petrova 13, 10000 Zagreb, Croatia
LJILJANA MIHALJEVIĆ ; Clinic of Gynecology and Obstetrics, Department for Anaesthesiology, CHC Zagreb, Petrova 13, 10000 Zagreb, Croatia
SLAVKO OREŠKOVIĆ ; Clinic of Gynecology and Obstetrics, School of Medicine, University of Zagreb, CHC Zagreb, Petrova 13, 10000 Zagreb
VESNA ELVEĐI-GAŠPAROVIĆ ; Clinic of Gynecology and Obstetrics, School of Medicine, University of Zagreb, CHC Zagreb, Petrova 13, 10000 Zagreb
TATJANA IGNJATIĆ ZOKIĆ ; Faculty of Chemical Engineering and Technology, Marulićev trg 19, 10000 Zagreb, Croatia
MARKO ĆAĆIĆ ; University of Zagreb, School of Medicine, Šalata 3, 10000 Zagreb

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Abstract

Background and Purposes: The aim of this study was to investigate the effect of epidurally administered S-(+)-ketamine on vasoactive stress hormones. It was a prospective study conducted after approval of the Ethical Committee and informed consent of patients.

Materials and Methods: The study was performed on 80 patients: 40
patients in Group 1 (0.5% bupivacaine) and 40 patients in Group 2 (0.5% bupivacaine + 25 mg S-(+)-ketamine – 0.326 mg/kg-bm). All patients were adults aged between 18 and 45 years, ASA I and II with epidural anaesthesia for a surgical procedure. Vasoactive parameters: concentrations of adrenaline, noradrenaline and cortisol were measured 30 minutes before setting the vein pathway and 17–25 min. after application of anaesthetics.

Results: There were no statistically significant changes in vasoactive
stress hormones (adrenaline, noradrenaline and cortisol) plasma concentrations after administering 0.5% bupivacaine, 0.5% bupivacaine + S-(+)- -ketamine epidurally.

Conclusion: Setting central nervous block before skin incision, using local anaesthetic, and S-(+)-ketamine, leaves concentrations of stress hormones in plasma within referent values. Adding a low dose of S-(+)- -ketamine into the epidural space in combination with 0.5% bupivacaine does not have an effect on the concentration of stress hormones in plasma.

Keywords

S-(+)-ketamine; epidural anaesthesia; vasoactive hormones

Hrčak ID:

38240

URI

https://hrcak.srce.hr/38240

Publication date:

15.6.2009.

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