Acta Pharmaceutica, Vol. 59 No. 4, 2009.
Original scientific paper
https://doi.org/10.2478/v10007-009-0035-6
Razvoj radiomarkiranog β-humanog koriogonadotropina
AMIR R. JALILIAN
; Nuclear Medicine Research Group, Agricultural, Medical and Industrial Research School (AMIRS), Karaj, Iran
MOHAMMAD REZA KHOSHDEL
; Islamic Azad University, Science and Research Branch, P. O. Box 14155-775, Tehran, Iran
JAVAD GAROUSI
; Nuclear Medicine Research Group, Agricultural, Medical and Industrial Research School (AMIRS), Karaj, Iran
HASSAN YOUSEFNIA
; Nuclear Medicine Research Group, Agricultural, Medical and Industrial Research School (AMIRS), Karaj, Iran
MOHAMMAD A. HOSSEINI
; Islamic Azad University, Science and Research Branch, P. O. Box 14155-775, Tehran, Iran
SAEED RAJABIFAR
; Nuclear Medicine Research Group, Agricultural, Medical and Industrial Research School (AMIRS), Karaj, Iran
DARYOUSH SARDARI
; Islamic Azad University, Science and Research Branch, P. O. Box 14155-775, Tehran, Iran
Abstract
Beta-humani korionski gonadotropin (beta-hCG) uspješno je markiran s [67Ga] galijevim kloridom nakon konjugacije sa svježe priređenim dianhidridom dietilentriaminpentaoctene kiseline (ccDTPA). Nakon čišćenja radiomarkiranog hormona na čvrstoj fazi, radiokemijska čistoća bila je prema HPLC veća od 95 % (specifična aktivnost = 22-23 TBq mM-1, učinkovitost markiranja 80 %). Preliminarni in vivo pokusi (ID g-1, %) na mužjacima divljeg tipa štakora pokazali su da obilježeni hormon značajno ulazi u gonade nakon 240 minuta, što je u suglasnosti s ispitivanjima biodistribucije i podacima o receptorima za beta-hCG. Omjer koncentracija u gonadama i krvi bio je 5,1, odnosno 15,2 nakon 3, odnosno 24 sata, dok je omjer koncentracija u gonadama i mišićima bio 35, odnosno 40 nakon 3, odnosno 24 sata.
Keywords
beta-hCG; radiomarkiranje; biodistribucija; radiofarmaka
Hrčak ID:
40497
URI
Publication date:
1.12.2009.
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