Original scientific paper

https://doi.org/10.2478/v10007-009-0031-x

Sinteza i preliminarna ispitivanja antikonvulzivnog djelovanja derivata benzotiazol-2-il tiadiazola

NADEEM SIDDIQUI ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi-110062, India
ARPANA RANA ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi-110062, India
SUROOR A. KHAN ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi-110062, India
S. EHTAISHAMUL HAQUE ; Department of Pharmacology, Faculty of Pharmacy, Hamdard University, New Delhi-110062, India
M. FAIZ ARSHAD ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi-110062, India
SHARIQUE Ahmed ; Department of Biochemistry, Faculty of Medicine, 7th October University, Misurata, Libya
WAQUAR AHSAN ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi-110062, India

Abstract

U radu je opisano dizajniranje i sinteza različitih N-(5-klor-6-supstituiranih-benzotiazol-2-il)-N'-(supstituiranih fenil)-[1,3,4]tiadiazol-2,5-diamina (5a-t) polazeći od odgovarajućih acetofenona. Strukture spojeva određene su na temelju spektroskopskih podataka i elementarne analize. Ispitano je antikonvulzivno djelovanje svih novosintetiziranih spojeva i uspoređeno s djelovanjem natrijeve soli fenitoina. Spojevi 5b i 5c pružaju potpunu zaštitu od konvulzija uzrokovanih MES-om, a svi spojevi štite od konvulzija u rasponu od 50 do 100 %.

Keywords

benzotiazol; tiadiazol; antikonvulziv; neurotoksičnost; hepatotoksičnost

Hrčak ID:

40501

URI

https://hrcak.srce.hr/40501

Publication date:

1.12.2009.

Article data in other languages: english

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