Original scientific paper
Microfracture Technique in Combination with Intraarticular Hyaluronic Acid Injection in Articular Cartilage Defect Regeneration in Rabbit Model
Dalen Legović
; Orthopaedic University Hospital Lovran, Lovran, Croatia
Sanja Zoričić
; Department of Anatomy, School of Medicine, University of Rijeka, Rijeka, Croatia
Gordan Gulan
; Orthopaedic University Hospital Lovran, Lovran, Croatia
Anton Tudor
; Orthopaedic University Hospital Lovran, Lovran, Croatia
Tomislav Prpić
; Orthopaedic University Hospital Lovran, Lovran, Croatia
Veljko Šantić
; Orthopaedic University Hospital Lovran, Lovran, Croatia
Dragica Bobinac
; Department of Anatomy, School of Medicine, University of Rijeka, Rijeka, Croatia
Branko Šestan
; Orthopaedic University Hospital Lovran, Lovran, Croatia
Radovan Mihelić
; Orthopaedic University Hospital Lovran, Lovran, Croatia
Hari Jurdana
; Orthopaedic University Hospital Lovran, Lovran, Croatia
Abstract
Although articular hyaline cartilage typically has low potential for regeneration, numerous methods and techniques have been proposed to induce the reparation process. In our work, we used microfracture techniques in combination with intraarticular application of hyaluronic acid in rabbit knee articular cartilage defect. In comparison with the control group, after 6 and 10 weeks we observed a higher potential of healing in the experimental group, with thicker and more organized repair tissue filling the defect. In conclusion, a combination of the microfracture technique and application of hyaluronic acid might be potentially beneficial in inducing articular cartilage defect reparation.
Keywords
hyaluronic acid; microfracture technique; cartilage reparation
Hrčak ID:
40566
URI
Publication date:
1.7.2009.
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