Original scientific paper

https://doi.org/10.2478/v10007-010-0001-3

Formulation and evaluation of multiple tablets as a biphasic gastroretentivefloating drug delivery system for fenoverine

SURESH BANDARI ; Centre for Biopharmaceutics and Pharmacokinetics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506 009 (A.P.), India
CHANDRA MOHAN EAGA ; Centre for Biopharmaceutics and Pharmacokinetics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506 009 (A.P.), India
ASHOK THADISHETTY ; Centre for Biopharmaceutics and Pharmacokinetics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506 009 (A.P.), India
MADHUSUDAN RAO YAMSANI ; Centre for Biopharmaceutics and Pharmacokinetics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506 009 (A.P.), India

Abstract

A biphasic gastroretentive drug delivery system of fenoverine was developed to maintain constant plasma concentration. The delivery system consisted of a loading-dose tablet and a floating multiple matrix tablet prepared by the direct compression process. The drug release from biphasic GRDDS in 0.1 mol L1 HCl and SGF (enzyme free) was sustained over 12 h with buoyant properties. Stability studies showed no significant change in dissolution profiles (f2 value > 50). Based on the release kinetics, it can be concluded that the floating multiple matrix tablet containing HPMC was a particularly suitable gastroretentive drug delivery system with a zero-order release profile.

Keywords

biphasic release; gastroretention; multiple matrix tablet; release kinetics

Hrčak ID:

41962

URI

https://hrcak.srce.hr/41962

Publication date:

1.3.2010.

Article data in other languages: croatian

Visits: 2.244 *