Review article
Global methods approach in deciphering the role of TFF2 proteins in organism
Mirela Baus Lončar
; Division of molecular medicine, Laboratory for systemic biomedicine, Rudjer Boskovic Institute, Zagreb, Croatia
Abstract
In the last fi ft een years a systemic approach has been widely implemented in
the investi gati on of diff erent proteins’ functi on as well as to elucidate the mechanisms underlying
disease development. Simultaneous monitoring of global changes through gene expression
studies combined with protein patt ern analyses represents the best way to unveil
the functi on of some proteins and/or pathogenesis mechanisms for various disease especially
when knowing that multi ple interacti on patt erns are present inside the cells and that
causes of diseases are oft en multi factorial. Trefoil factor family proteins (TFFs) have been
discovered more than 25 years ago. It has soon become clear that their role in biological
systems is multi factorial and quite complex. A systemic approach to their analyses brought
out the role of TFF2 involvement in the processes relevant for the immune system.
Keywords
gastrointestinal defence; immune system; TFF proteins; TFF2
Hrčak ID:
43668
URI
Publication date:
1.9.2009.
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