Original scientific paper

Prevalence of Bisphosphonate Associated Osteonecrosis of the Jaws in Breast Cancer Patients

Christian Walter ; Klinik für Mund- Kiefer- und Gesichtschirurgie, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Germany
Knut A. Grötz ; Klinik für Mund- Kiefer- und Gesichtschirurgie, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz; Klinik für Mund-Kiefer-Gesichtschirurgie, der HSK Dr. Horst Schmidt Klinik, Wiesbaden, Germany
Adrian Kašaj ; Poliklinik für Zahnerhaltungskunde, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Germany
Stefan Albricht ; Klinik und Poliklinik für Geburtshilfe und Frauenheilkunde, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Germany
Marcus Schmidt ; Klinik und Poliklinik für Geburtshilfe und Frauenheilkunde, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Germany
Bastian Nauroth ; Klinik für Mund- Kiefer- und Gesichtschirurgie, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Germany
Bilal Al-Nawas ; Klinik für Mund- Kiefer- und Gesichtschirurgie, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Germany

Abstract

Objective: To evaluate the prevalence of Bisphosphonate-associated-osteonecrosis-of-the-jaws (BP-ONJ) and protective factors of BP-ONJ-development in breast cancer patients with osseous metastasis and bisphosphonate therapy using systematical dental oral examinations. Material and Methods: A cross-sectional-study was conducted in the Department for Gynecology in Mainz, Germany. All breast cancer patients (n=51) treated with bisphosphonate in the time span from 07/2006 to 09/2007 were recruited. Primary outcome was the development of BP-ONJ and the detection of possible additional trigger factors for the development of BP-ONJ, as well as possible factors for avoiding BP-ONJ. Results: Only 1 out of 51 patients developed BP-ONJ (2.0%). A tooth extraction could be identified as an additional trigger factor. The overall dental hygiene of this patient clientele was above average. Conclusion: Compared to other alignant diseases, BP-ONJ in breast cancer patients does not appear as often. The underlying disease might be of importance in the development of BP-ONJ. A good dental hygiene might be a protective factor.

Keywords

Bisphosphonates; Osteonecrosis; Jaw diseases; Breast cancer; Oral hygiene

Hrčak ID:

44905

URI

https://hrcak.srce.hr/44905

Publication date:

15.12.2009.

Article data in other languages: croatian

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