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Original scientific paper

The Antiresorptive Effect of Intracanal Application of Alendronate in Canine Model

Samir Prohić ; School of Dental Medicine University of Sarajevo, Bosnia and Herzegovina
Enita Nakaš ; School of Dental Medicine University of Sarajevo, Bosnia and Herzegovina

Full text: croatian pdf 483 Kb

page 301-309

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Full text: english pdf 483 Kb

page 301-309

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Use of root resorption-inhibiting substances may be an alternative in cases of unsuccessful reimplantation of the teeth. Objective: The aim of this study was to test a solution of Alendronate (ALN), as an intracanal therapeutic agent for late replanted teeth. Material and methods: Mandibular premolar mature roots of four dogs were used in the study. The roots were endodontically treated, then extracted and bench dried for 45 minutes. Thereafter, the teeth were divided into two groups: Group I: intracanal dressing with solution of 1mMol ALN and topical application of ALN 1mMol, Group II: topical application of ALN 1mMol. Teeth were then replanted in their respective sockets. The animals were sacrificed four months after replantation and the samples processed for morphometric and microscopic analysis. The residual root mass was measured to determine the extent of root structure loss. Results: Statistical analysis performed with the Scheffe F multiple comparison test revealed significant differences among treatment groups (p<0.005). Conclusion: The results indicate that alendronate was able to reduce root resoprtion when applied as intracanal solution and topical solution more efficiently than when applied solely as topical solution.


Tooth Replantation, Tooth Root, Tooth Avulsion, Alendronate

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