Review article
https://doi.org/10.2478/10004-1254-60-2009-1969
A Journey Through Mitogen-Activated Protein Kinase and Ochratoxin A Interactions
Lada Rumora
orcid.org/0000-0002-5302-3770
; Faculty of Pharmacy and Biochemistry, Department of Medical Biochemistry and Haematology, Zagreb, Croatia
Tihana Žanić Grubišić
; Faculty of Pharmacy and Biochemistry, Department of Medical Biochemistry and Haematology, Zagreb, Croatia
Abstract
Ochratoxin A (OTA) is a ubiquitous mycotoxin with potential nephrotoxic, carcinogenic, and cytotoxic action. It has been proposed that OTA might be involved in the development of Balkan endemic nephropathy, which is associated with an increased risk of urinary tract tumours, and of other forms of interstitial nephritis. Cell susceptibility to OTA mainly depends on mycotoxin concentrations, duration of exposure, and intracellular molecular and genetic context. OTA can affect a cell by stimulating or inhibiting certain signalling pathways such as mitogen-activated protein kinase (MAPK). Three major mammalian MAPKs have been described: extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinase (JNK),
and p38 MAPK. All MAPKs regulate diverse cellular programmes, but in most cases ERKs have been linked to cell survival, while JNKs, and p38 MAPKs have been implicated in cell death by apoptosis. This
review looks into OTA-mediated MAPK activation and its effects.
Keywords
apoptosis; carcinogenicity; kidney; necrosis; oxidative stress; toxicity
Hrčak ID:
45391
URI
Publication date:
22.12.2009.
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