Original scientific paper

Synthesis, Structure and Cytotoxicity of Platinum(IV) Complexes of 3-Aminocyclohexanespiro-5-hydantoin and 3-Aminocycloheptanespiro-5-hydantoin

Daniel Kushev ; Institute of Molecular Biology, Bulgarian Academy of Sciences, BG-1113 Sofia, Bulgaria
Venelin Enchev ; Institute of Organic Chemistry, Bulgarian Academy of Sciences, BG-1113 Sofia, Bulgaria
Emilya Naydenova ; Department of Organic Chemistry, Chemical Technology and Metallurgy University, BG-1756 Sofia, Bulgaria
Roumiana Detcheva ; Institute of Molecular Biology, Bulgarian Academy of Sciences, BG-1113 Sofia, Bulgaria
Nadejda Spassovska ; Institute of Molecular Biology, Bulgarian Academy of Sciences, BG-1113 Sofia, Bulgaria
Konstantin Grancharova ; Institute of Molecular Biology, Bulgarian Academy of Sciences, BG-1113 Sofia, Bulgaria

Abstract

Two new platinum(IV) complexes of 3-aminocyclohexanespiro-5-hydantoin (achsh) and 3-aminocycloheptanespiro-5-hydantoin (achpsh) were prepared and characterized. Abinitio calculation of the structure and the measurements of IR and NMR spectra of complexes were also performed. The complexes were evaluated for invitro cytotoxicity in murine erythroleukemia (MEL) cells, clone F4N. The complexes exerted low invitro toxicity, comparable with that of the corresponding platinum(II) complexes.

Keywords

platinum(IV) complexes; molecular structure; cytotoxic effect; ab initio calculations

Hrčak ID:

45442

URI

https://hrcak.srce.hr/45442

Publication date:

11.12.2009.

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