Review article
HPV-Genital Infections, Men and the HPV Vaccine: New Horizons
Mihael Skerlev
; Medicinski fakultet Sveučilišta u Zagrebu
Abstract
Up to 150 HPV DNA types have been identified so far. Anogenital warts (condylomata acuminata) are the most common lesions presented in men. However, during the last decade the other HPV-associated lesions such as condylomata plana, penile, scrotal, and anal intraepithelial neoplasias, as well as the penile, urine bladder and prostate cancer have been studied a little bit more extensively. The clinical variations might range from clinically "invisible", "asymptomatic" lesions to the bizarre forms of giant condyloma of Buschke-Löwenstein type, including Bowenoid papulosis, Mb. Bowen, different kinds of erythroplasia in both men and women and a large spectrum of HPV-induced dermatovenereological entities in genital region including high-grade intraepithelial genital neoplasias, such as penile, anal, scrotal, vulvar, vaginal etc. (thus not only cervical), and, last but not least, anogenital warts. In general, anogenital infections caused by Human papillomavirus (HPV) are the most frequently diagnosed sexually transmitted infections (STIs) of viral origin. A prophylactic vaccine that targets these types should thus substantially reduce the burden of HPV-associated clinical diseases. Ultimately, within the spectrum of therapeutic options for condylomata, no method is really superior to others; recurrences occurred in 30-70% of cases. We definitely need the HPV vaccination program to eradicate
one of the oldest and up to now unsolved problems of mankind. Since HPV is transmitted by sexual intercourse, managing both partners is necessary in order to eliminate the virus in the population. The appropriate approaches include prophylactic vaccines such as the quadrivalent HPV vaccine for both men and women.
Keywords
HPV; men; clinical spectrum; HPV vaccine
Hrčak ID:
48236
URI
Publication date:
19.2.2009.
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