Original scientific paper

https://doi.org/10.2478/10004-1254-61-2010-1986

Brain Toxicokinetics of Prometryne in Mice

Domagoj Đikić ; Department of Animal Physiology, Faculty of Science, University of Zagreb, Zagreb, Croatia
Lana Sajli ; Forensic Centre Ivan Vučetić, Ministry of Interior, Zagreb, Croatia
Vesna Benković ; Department of Animal Physiology, Faculty of Science, University of Zagreb, Zagreb, Croatia
Anica Horvat Knežević ; Department of Animal Physiology, Faculty of Science, University of Zagreb, Zagreb, Croatia
Gordana Brozović ; University Hospital for Tumours, Zagreb, Croatia
Duje Lisičić ; Department of Animal Physiology, Faculty of Science, University of Zagreb, Zagreb, Croatia
Ana Mojsović ; College of Applied Health Studies, Zagreb, Croatia
Nada Oršolić ; Department of Animal Physiology, Faculty of Science, University of Zagreb, Zagreb, Croatia

Abstract

Prometryne is a methylthio-s-triazine herbicide. Signifi cant trace amounts are found in the environment,
mainly in water, soil, and food plants. The aim of this study was to establish brain and blood prometryne levels after single oral dose (1 g kg-1) in adult male and female mice. Prometryne was measured using the GC/MS assay at 1, 2, 4, 8, and 24 h after prometryne administration. Peak brain and blood prometryne values were observed 1 h after administration and they decreased in a time-dependent manner. Male mice had consistently higher brain and blood prometryne levels than female mice. The observed prometryne
kinetics was similar to that reported for the structurally related herbicide atrazine.

Keywords

blood; herbicide; nervous system; toxicity; triazine

Hrčak ID:

49013

URI

https://hrcak.srce.hr/49013

Publication date:

17.3.2010.

Article data in other languages: croatian

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