Review article
https://doi.org/10.2478/10004-1254-61-2010-1942
Allergotoxicology: Research of Pollutant Influence on the Development of Allergic Reactions
Božica Kanceljak-Macan
; Institut za medicinska istraživanja i medicinu rada, Zagreb, Hrvatska
Abstract
Allergotoxicology studies the infl uence of pollutants on the development of allergic reactions and diseases. At the beginning, the research was focused on outdoor air pollutants, while recently it turns to the indoor environment, mainly because people this is where people spend most of their time. Air pollutants may be solid, soluble, or gaseous particles in nature, and they can differ in size, structure, and sources. Pollutants can be of biological or nonbiological origin. Currently interesting air pollutants include particulate matter, ozone, nitrogen oxides, and bioaerosols. The mechanisms of pollutant activity depend on the particle size, solubility, site of deposition, and specifi c chemical properties. Recent studies have shown that different pollutants provoke different immunological and nonimmunological responses in exposed persons. Interaction between air pollutants and allergens can take place outside the exposed person i.e. with allergen itself, or inside the organism on mucous membranes and skin. Pollutants may be the carriers of allergens and may exacerbate allergic reactions and diseases. This review presents recent views about the mechanisms of pollutant activity on allergens and immune system response in exposed persons, based on epidemiological population studies, clinical studies of exposure under controlled conditions, and experimental tests in vitro and in vivo.
Keywords
air polluants; allergens; asthma; bioaerosols; IgE antibody; LLNA; particulate matter; pollen allergy; protein-hapten conjugates
Hrčak ID:
49023
URI
Publication date:
17.3.2010.
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