Original scientific paper

Synthesis and antimicrobial evaluation of some new thienopyrimidine derivatives

MD. MOSHAREF HOSSAIN BHUIYAN
KHANDKER MD. MIZANUR RAHMAN
MD. KAMRUL HOSSAIN
ABDUR RAHIM
ISMAIL HOSSAIN
MOHAMMAD ABU NASER

Abstract

Reaction of heteroaromatic o-aminonitrile with ethyl N-/bis(methylthio)methyleneamino acetate resulted in annelation of a thieno/3,2-e/imidazo/1,2-c/pyrimidine moiety in a one step process. /1,2,4/Triazolo/4,3-c/thieno/3,2-e/pyrimidine derivatives were prepared by initial treatment of o-aminonitrile with carbon disulfide, followed by methylation with methyl iodide and subsequent reaction with benzhydrazide and thiosemicarbazide, respectively. Hydrazinothieno/2,3-d/pyrimidine was prepared by cyclization of heteroaromatic o-aminoester with formamide, followed by chlorination and subsequent displacement with hydrazine. Treatment of the hydrazine derivative with acetylacetone, benzaldehyde and acetic anhydride afforded pyrazolylpyrimidine, benzylidenehydrazonopyrimidine and trizolopyrimidine derivatives, respectively. Some of these derivatives exhibited pronounced antimicrobial activity.

Keywords

imidazopyrimidine; triazolopyrimidine; antimicrobial activity

Hrčak ID:

4615

URI

https://hrcak.srce.hr/4615

Publication date:

1.12.2006.

Article data in other languages: croatian

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