Review article

Antibiotic sensitivity of enterobacteriaceae

Saša Andrašević ; Klinika za infektivne bolesti "Dr. Fran Mihaljević", Zagreb, Hrvatska
Mirna Vranić-Ladavac ; Zavod za javno zdravstvo Istarske županije, Pula, Hrvatska
Arjana Tambić-Andrašević ; Klinika za infektivne bolesti "Dr. Fran Mihaljević", Zagreb, Hrvatska

Abstract

Enterobacteriaceae are important pathogens in urinary tract infections (UTI), gastrointestinal and healthcare associated infections. When deciding on empirical antibiotic therapy intrinsic resistance mechanisms present in certain bacterial species should be considered but even more worrisome problem is the presence of numerous, always changing, mechanisms of acquired resistance. Beta-lactam antibiotics are the most frequently used antibiotics in clinical practice and trimethoprim-sulfamethoxazole (co-trimoxazole) and the quinolones are precious drugs in the treatment of UTI and gastrointestinal infections due to their ability to eradicate pathogens from these sites. Numerous resistance mechanisms have emerged to all these groups of antibiotics and often different mechanisms are present in the same strain. In Croatia, E. coli isolates resistance rates are 3% for the 3rd generation cephalosporins, 24% for co-trimoxazole and 11% for ciprofloxacin. K. pneumoniae more often causes healthcare associated infections and has higher rates of resistance; 29% for 3rd generation cephalosporins and 36% for co-trimoxazole and ciprofloxacin. In Croatia carbapenem resistance in enterobacteriaceae is still sporadic.

Keywords

enterobacteriaceae; beta-lactams; quinolones; co-trimoxazole; resistance

Hrčak ID:

50623

URI

https://hrcak.srce.hr/50623

Publication date:

4.12.2009.

Article data in other languages: croatian

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