Preliminary communication
Hodgkin’s Lymphoma Variant of Richter’s Syndrome
Ankica Vasilj
; Department of Cytology, University Clinic of Internal Medicine, University Hospital »Sestre Milosrdnice«, Zagreb, Croatia
Sandra Kojić-Katović
; Department of Cytology, University Clinic of Internal Medicine, University Hospital »Sestre Milosrdnice«, Zagreb, Croatia
Ivana Maričević
; Department of Cytology, University Clinic of Internal Medicine, University Hospital »Sestre Milosrdnice«, Zagreb, Croatia
Edita Žokvić
; Department of Cytology, University Clinic of Internal Medicine, University Hospital »Sestre Milosrdnice«, Zagreb, Croatia
Iva Bobuš Kelčec
; Department of Cytology, University Clinic for Tumors, Zagreb, Croatia
Davor Tomas
; University of Zagreb, School of Medicine, Zagreb, Croatia
Silva Ćurić-Jurić
; Department of Cytology, University Clinic of Internal Medicine, University Hospital »Sestre Milosrdnice«, Zagreb, Croatia
Abstract
Chronic lymphocytic leukemia/small lymphocitic lymphoma (CLL/SLL) is low-grade malignant lymphoprolipheration, that has tendency to conwert to a higher-grade neoplasam over time. More common is the development of a diffuse large cell lymphoma or transformation into prolymphocytic cell population. In rare cases, 0.1–0.5% of patients develop multiple myeloma or Hodgkin’s disease. We present 65-year old female with Hodgkin’s variant of Richter’s syndrome. On the basis of clinical simptoms, cytological, hystological and immunohistological finding in April 2008 CLL/SLL were diagnosed. The patient was treated with 8 courses of R-CHOP. After 10 month, FNA of the one of the enlarged lymph node on the neck was performed. The diagnosis was Hodgkin’s disease. Immuno-hystological studies of the lymph node was consistent with type I Hodgkin’s type of Richter’s syndrome. Patient was treated with 3 courses of ABVD and radiotherap.
Keywords
Richter’s syndrome; chronic lymphocytic leukemia; Hodgkin’s disease; Reed-Sternberg cell
Hrčak ID:
51282
URI
Publication date:
10.3.2010.
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