Review article

Monocytes in Metabolic Disorders – Opportunities for Flow Cytometry Contributions

Vlatka Pandžić Jakšić ; Department of Endocrinology and Metabolism, University Hospital Dubrava, Zagreb, Croatia
Branimir Gizdić ; Department of Clinical Cytology and Cytometry, University Hospital Dubrava, Zagreb, Croatia
Zorana Miletić ; University of Applied Health Studies, Zagreb, Croatia
Karmen Trutin Ostović ; University of Applied Health Studies, Zagreb, Croatia
Ozren Jakšić ; University of Zagreb, School of Medicine, Zagreb, Croatia

Abstract

Chronic inflammation has arised as a major underlying cause of atherosclerosis, obesity and diabetes. It is mediated by cells of innate immune system like macrophages but also by their antecedents, circulating monocytes. Roles of monocyte subsets and different markers of monocyte activation in the context of metabolic disorders have been reviewed. Applying cell based approach through flow cytometry in this field has resulted with new understanding of pathophysiologic mechanisms. Possible implications of these insights in diagnosis, prognosis and revealing of therapeutic targets in metabolic disorders remain a challenge for future.

Keywords

monocytes; metabolism; atherosclerosis; obesity; flow cytometry

Hrčak ID:

51286

URI

https://hrcak.srce.hr/51286

Publication date:

10.3.2010.

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