Original scientific paper

Design of dermal electrospun replacement

Ante Agić ; Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 19, 10000 Zagreb, Croatia
Milorad NIKITOVIĆ ; College for Information Technologies, 10000 Zagreb, Croatia
BUDIMIR MIJOVIĆ ; Faculty of Textile Technology, University of Zagreb, Prilaz b. Filipovića 28a, 10000 Zagreb, Croatia

Abstract

Background and Purpose: This study is related to the design of advanced dermal scaffolds (non-woven fibrous mats) to provide multifunctional properties.

Materials and Methods: The nanofibre fabric from poly (ε-caprolactone) (PCL) solutions in acetone were produced by electrospinning. Based on SEM and its stochastic fibre characterization, equivalent fabric was generated by computer. Fibres network was created by random deposition of elastic straight segments within a representative volume element
(RVE).Elastic and permeability properties determined experimentally and numerically.

Results: The fibres diameter produced fibrous structure depends on solution concentration and electric field, what have been identified by surface response methodology. Effective Young’s modules for fibrous network measured and predicted by numerical model depend on fibres density and fibres diameter. Calculated data for permeability and pore distributionwere compared with models for fibrous media with acceptable error level.

Conclusions: Effective elastic and permeability properties are determined by separate computational models. The scaffold multiscale behaviour is commented with multiphysic design procedure.

Keywords

electrospinninig; dermal scaffold; multiscale design

Hrčak ID:

52762

URI

https://hrcak.srce.hr/52762

Publication date:

31.3.2010.

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