Original scientific paper

Pharmacokinetics of ceftriaxone in calves

Jayesh J. Maradiya ; epartment of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, India
Harshad V. Goriya ; epartment of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, India
Shailesh K. Bhavsar ; epartment of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, India
Urvesh D. Patel ; epartment of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, India
Aswin M. Thaker ; epartment of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, India

Abstract

The pharmacokinetics of ceftriaxone was determined after a single intravenous and intramuscular administration at the dose rate of 10 mg/kg in crossbred cow calves. The drug concentration in plasma was quantified through High Performance Liquid Chromatography with UV detection. Following intravenous administration the drug was rapidly distributed (t1/2α: 0.13 ± 0.01 h; Vd(area); 0.44 ± 0.07 L/kg) and eliminated (t1/2β: 1.58 ± 0.06 h) from the body with a clearance rate of 3.15 ± 0.41 mL/min/kg. Following intramuscular administration, the peak plasma drug concentration (Cmax) was 15.34 ± 2.39 μg/mL at 0.25 hours (Tmax) suggesting very rapid absorption. The drug was extensively distributed (Vd(area): 1.16 ± 0.15 L/kg) and slowly eliminated (t1/2β: 5.02 ± 0.51 hours; Cl(B): 2.71 ± 0.29 mL/min/kg) following intramuscular administration. The absolute bioavailability of ceftriaxone was 47.0 ± 5.0% following intramuscular injection. However, it can be used at a dosage of 10 mg/kg intramuscularly, repeated at twelve-hourly intervals, for the treatment of susceptible bacteria infections in calves.

Keywords

pharmacokinetics; bioavailability; ceftriaxone; intravenous; intramuscular; cow; calves

Hrčak ID:

53094

URI

https://hrcak.srce.hr/53094

Publication date:

8.3.2010.

Article data in other languages: croatian

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