Review article

Iron overload as a consequence of red blood cell transfusions in patients with hematological diseases

Toni Valković ; Department of hematology, reaumathology and clinical immunology, Clinical hospital centre Rijeka, Rijeka, Croatia
Duška Petranović ; Department of hematology, reaumathology and clinical immunology, Clinical hospital centre Rijeka, Rijeka, Croatia
Antica Načinović-Duletić ; Department of hematology, reaumathology and clinical immunology, Clinical hospital centre Rijeka, Rijeka, Croatia
Ivan Host ; Department of hematology, reaumathology and clinical immunology, Clinical hospital centre Rijeka, Rijeka, Croatia

Abstract

Iron overload is a very common and serious complicati on of repeated red blood cell transfusions which contributes to organ dysfuncti on and influences survival in patients with hematological diseases. Several methods for measuring ti ssue iron content are used in every-day practice. Iron chelation therapy is recommanded when serum ferriti n levels reach 1000 ug/L and/or in pati ents who have previously received more then 20 units of red blood cell. Effective iron chelators are essenti al in the management of iron overload of hematological patients that require repeted blood transfusions with proved reducti on of morbidity and improvement of their quality of life.

Keywords

blood transfusion; ferritin; iron; hematological diseases; iron chelators; iron overload

Hrčak ID:

53217

URI

https://hrcak.srce.hr/53217

Publication date:

7.6.2010.

Article data in other languages: croatian

Visits: 3.234 *