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Acta Pharmaceutica, Vol. 60 No. 3, 2010.

Original scientific paper

https://doi.org/10.2478/v10007-010-0025-8

Design and evaluation of taste masked dextromethorphan hydrobromide oral disintegrating tablets

MADHUSUDHAN MALLADI ; CPS Formulations, DR. Reddy’s Laboratories Limited, Bachupally, Hyderabad-500090, India
RAJU JUKANTI ; Department of Pharmaceutics, St. Peter’s Institute of Pharmaceutical Sciences, Vidyanagar, Hanamkonda, Warangal-506001, India
RASHMI NAIR ; CPS Formulations, DR. Reddy’s Laboratories Limited, Bachupally, Hyderabad-500090, India
SANJAY WAGH ; CPS Formulations, DR. Reddy’s Laboratories Limited, Bachupally, Hyderabad-500090, India
HARI SHANKER PADAKANTI ; Department of Pharmaceutics, St. Peter’s Institute of Pharmaceutical Sciences, Vidyanagar, Hanamkonda, Warangal-506001, India
ASHOK MATETI ; Department of Pharmaceutics, St. Peter’s Institute of Pharmaceutical Sciences, Vidyanagar, Hanamkonda, Warangal-506001, India

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Abstract

The present study is aimed to develop dextromethorphan hydrobromide (DXM) oral disintegrating tablets (ODT) with acceptable palatability to help patients of all age group. The bitter taste of the drug was masked by binding the drug to ion exchange resin. The effect of particle size of resin on drug loading was studied. In vitro and in vivo disintegration time and in vitro drug release studies were performed. Drug loading increased significantly with a decrease in the particle size of the resin. DSC and XRPD studies reveal that the molecular state of the drug changed from crystalline to amorphous form. The dissolution efficiency calulated for optimized ODT and conventional directly compressed tablet were almost comparable, indicating free dissociation of the drug from the resinate. The bitter taste of DXM can be masked by binding with ion exchange resin and the resinate can be successfully formulated into oral disintegrating tablets.

Keywords

dextromethorphan hydrobromide; ion exchange resin; taste masking; superdisintegrants

Hrčak ID:

53495

URI

https://hrcak.srce.hr/53495

Publication date:

1.9.2010.

Article data in other languages: croatian

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