Original scientific paper

https://doi.org/10.2478/v10007-010-0028-5

Evaluacija svojstava vezanja sluzi sjemenki biljke Plantago psyllium

MAJID SAEEDI ; Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
KATAYOUN MORTEZA-SEMNANI ; Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran, Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
FARSHAD ANSOROUDI ; Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
SAEED FALLAH ; Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
GHOLAMREZA AMIN ; Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Abstract

U radu je ispitivana neškodljivost i sigurnost uporabe sluzi ekstrahirane iz sjemenki biljke Plantago psyllium. Primjenjivost te sluzi kao veziva u farmaceutskim pripravcima ispitana je na tabletama paracetamola. Granule pripravljene s različitim koncentracijama sluzi uspoređene su s granulama s PVP-om i tragakantom. Sluz s udjelom 5 % (m/m) usporediva je s otopinom PVP-a masenog udjela 3 %. Pripravljene tablete paracetamola ukazuju na to da ispitivana sluz može usporiti oslobađanje lijeka.

Keywords

Plantago psyllium (Plantaginaceae); sluz; paracetamol; vezivo; oslobađanje

Hrčak ID:

53498

URI

https://hrcak.srce.hr/53498

Publication date:

1.9.2010.

Article data in other languages: english

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