Original scientific paper

https://doi.org/10.2478/v10007-010-0028-5

Evaluation of binding properties of Plantago psyllium seed mucilage

MAJID SAEEDI ; Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
KATAYOUN MORTEZA-SEMNANI ; Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran, Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
FARSHAD ANSOROUDI ; Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
SAEED FALLAH ; Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
GHOLAMREZA AMIN ; Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Abstract

Mucilage extracted from Plantago psyllium seeds was evaluated for inertness and safety parameters. The suitability of psyllium mucilage for a pharmaceutical binder was assessed in paracetamol tablets. Properties of the granules prepared using different concentrations of psyllium mucilage was compared with PVP and tragacanth. Psyllium mucilage at 5 % (m⁄m) level was found to be comparable with 3 % (m⁄m) of PVP. Investigated paracetamol tablets indicated that psyllium mucilage can retard the drug release.

Keywords

Plantago psyllium; mucilage; paracetamol; binder; release

Hrčak ID:

53498

URI

https://hrcak.srce.hr/53498

Publication date:

1.9.2010.

Article data in other languages: croatian

Visits: 3.342 *