Original scientific paper
Met-Enkephalin Effects on Histamine-Induced Bronchoconstriction in Guinea Pigs
Dorian Tješić-Drinković
Nikola Štambuk
Duška Tješić-Drinković
Paško Konjevoda
Nikola Gotovac
Tihomir Ćurković
Ana Votava-Raić
Abstract
We investigated the effects of the neuropeptide met-enkephalin on histamine-induced bronhoconstriction in an experimental model of asthma. Classic Konzett and Rössler’s method of whole body plethysmography modified by Gjuriš, was applied in the study. This method represents a standard experimental model of bronchoconstriction, suitable
for the evaluation of peptide effects on the histamine-induced bronchoconstriction. The results of the measurements implicate a dose-related modulatory effect of met-enkephalin on the bronchoconstrictor action of histamine. Met-enkephalin doses of 1 mg/kg and 10 mg/kg, respectively, caused statistically significant reduction of the histamine-induced
bronchoconstriction. Estimated ED50 dose was 0.235 mg/kg. Further studies are needed to define practical and therapeutical use of the presented observations in respiratory pharmacology.
Keywords
met-enkephalin; bronhoconstriction; histamine; asthma; plethysmography
Hrčak ID:
5330
URI
Publication date:
15.12.2005.
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