Original scientific paper
The –429 T/C and –374 T/A Gene Polymorphisms of the Receptor of Advanced Glycation End Products Gene (RAGE) are not Risk Factors for Coronary Artery Disease in Slovene Population With Type 2 Diabetes
Janez Kirbiš
Aleksandra Milutinović
Klemen Steblovnik
Nataša Teran
Rifet Terzić
Marjeta Zorc
Abstract
Receptor for advanced glycation end products (RAGE) plays a role in atherosclerosis in diabetics. There are two functional polymorphisms in the promoter of the RAGE gene (–429T/C and –374T/A). The aim of this study was to look for a relationship between the –429T/C and the –374T/A gene polymorphisms of the RAGE gene and the development of coronary artery disease (CAD) in the Slovene population with type 2 diabetes of duration longer than 10 years. One hundred and sixty-eight subjects with diabetes and CAD were compared to 241 diabetic subjects without CAD. The –429T/C and the –374T/A RAGE genotype distributions in patients with CAD (–429T/C: CC: 3%, TC: 31%, TT: 66.0%; 374T/A: AA: 7.7%, TA: 48.2%, TT: 44.1%) were not significantly different from those in patients without CAD (–429 T/C: CC: 1.7%, TC: 26.1%, TT: 72.2%; –374T/A: AA: 11.2%, TA: 43.2%, TT: 45.6%). Our study failed to demonstrate an association between either the –429T/C or the –374T/A gene polymorphism of the RAGE gene and CAD in the Slovene population with type 2 diabetes of duration longer than 10 years.
Keywords
RAGE; –429 T/C, –374 T/A, coronary artery disease, Caucasians, type 2 diabetes, genetic risk factors
Hrčak ID:
5583
URI
Publication date:
15.12.2004.
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