Short communication, Note

Acute effects of doramectin on gastric acid secretion in anaesthetized rats - a short communication

Kennedy Erlwanger ; School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Parktown, South Africa
Terence Changara ; Preclinical Veterinary Department, Faculty of Veterinary Science, University of Zimbabwe, Mt Pleasant, Harare, Zimbabwe
Shepherd Sajeni ; Preclinical Veterinary Department, Faculty of Veterinary Science, University of Zimbabwe, Mt Pleasant, Harare, Zimbabwe
Darlington Masara ; Preclinical Veterinary Department, Faculty of Veterinary Science, University of Zimbabwe, Mt Pleasant, Harare, Zimbabwe

Abstract

To investigate the acute effects of doramectin on basal and histamine-stimulated gastric secretion in anaesthetised rats, twenty adult female Sprague-Dawley rats were anaesthetised and their stomachs were cannulated and perfused with saline. Basal gastric acid secretion was collected from all rats. Doramectin (300 μg.kg-1, n = 5 and 600 μg.kg-1, n = 5) was then administered to ten rats intramuscularly, followed an hour later by histamine (100 μg.kg-1) subcutaneously. In another 10 rats the histamine was administered an hour before the doramectin. There was no significant change in gastric acid secretion compared to when doramectin alone was administered. Histamine, produced a significant increase (P<0.01) in gastric acid secretion. Doramectin neither potentiated nor decreased the effect of histamine on gastric acid secretion.

Keywords

gastric acid; doramectin; rats; gamma amino butyric acid

Hrčak ID:

58467

URI

https://hrcak.srce.hr/58467

Publication date:

28.7.2010.

Article data in other languages: croatian

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