Original scientific paper

https://doi.org/10.2478/v10007-010-0033-8

Antimicrobial activity of some synthesized glucopyranosyl-pyrimidine carbonitrile and fused pyrimidine systems

HAYAM H. SAYED ; Photochemistry Department, National Research Centre, 12622 Dokki, Cairo, Egypt
HEBAT-ALLAH S. ABBAS ; Photochemistry Department, National Research Centre, 12622 Dokki, Cairo, Egypt
EMAN M. H. MORSI ; Photochemistry Department, National Research Centre, 12622 Dokki, Cairo, Egypt
ABD EL-GALIL E. AMR ; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
NAYERA A. M. ABDELWAHAD ; Chemistry of Natural and Microbial Product Department, National Research Centre, 12622 Dokki, Cairo, Egypt

Abstract

3-Amino-5-(4-chlorophenylamino)-4-cyanofuran-2-carboxamide (2) was used as the key molecule for preparation of various furo- pyrimidines 3-9 and formation of spiro-cycloalkane furopyrimidines 10, 11. Also, poly fused heterocyclic compounds 13-17 were prepared from compound 2. The synthesized compounds were screened for their antimicrobial activity.

Keywords

pyrimidine; glucopyranosyl-pyrimidine; oxazine; antimicrobial activity

Hrčak ID:

59305

URI

https://hrcak.srce.hr/59305

Publication date:

1.12.2010.

Article data in other languages: croatian

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