Review article
The Role of Oxygen in Cardiac Arrest Resuscitation
Mark G. Angelos
; The Ohio State University, 1654 Upham Drive, Columbus, OH 43210
Abstract
The heart is incapable of storing significant oxygen or substrates and thus is entirely dependent on a continuous delivery
of flow in order to support its high metabolic state. Following cardiac arrest, myocardial tissue oxygen tension falls rapidly
and aerobic production of ATP ceases. Without re-oxygenation of the ischemic myocardium, return of spontaneous circulation
(ROSC) cannot be achieved. The oxygen paradox which has been described regarding other ischemia-reperfusion
conditions seems to have application in cardiac arrest. It is clear that some level of oxygenation is necessary to achieve
ROSC, however post ROSC there appears to be increased toxicity associated with hyperoxia. The optimal conditions for
re-oxygenation in the setting of cardiac arrest remain ill defined at present.
Keywords
cardiac arrest; oxygen; myocard; oxygen delivery; Adenosine- 5'-triphosphate (ATP); mitochondria; measurement of tissue oxygen; oxygen paradox
Hrčak ID:
59433
URI
Publication date:
1.9.2010.
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