Review article

https://doi.org/10.2478/v10007-010-0037-4

Ordered mesoporous silicates as matrices for controlled release of drugs

TINA UKMAR ; National Institute of Chemistry, Slovenia, 1001 Ljubljana, Slovenia
ODON PLANINŠEK ; University of Ljubljana, Faculty of Pharmacy, 1000 Ljubljana, Slovenia

Abstract

Interest in and thereby also in development of ordered mesoporous silicates as drug delivery devices have grown immensely over the past few years. On hand selected cases from the literature, the power of such systems as delivery devices has been established. Specifically, it is shown how it is possible to enhance the release kinetics of poorly soluble drugs by embedding them in mesoporous silicates. Further critical factors governing the structure and release of the model drug itraconazole incorporated in an SBA-15 matrix are briefly reviewed. The possibility of functionalizing the surface of mesoporous matrices also under harsher conditions offers a broad platform for the design of stimuli-responsive drug release, including pH responsive systems and systems which respond to the presence of specific ions, reducing agents, magnetic field or UV light, whose efficiency and biocompatibility has been established in vitro.

Keywords

mesoporous silicates; drug delivery; modified release

Hrčak ID:

59505

URI

https://hrcak.srce.hr/59505

Publication date:

1.12.2010.

Article data in other languages: slovenian

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