Review article

NHE-1 Inhibitors and Erythropoietin for Maintaining Myocardial Function during Cardiopulmonary Resuscitation

Raul J. Gazmuri orcid.org/0000-0002-3848-7227 ; Rosalind Franklin University of Medicine and Science, North Chicago VA Medical Center
Iyad M. Ayoub ; Rosalind Franklin University of Medicine and Science, North Chicago VA Medical Center
Jeejabai Radhakrishnan ; Rosalind Franklin University of Medicine and Science, North Chicago VA Medical Center

Abstract

Efforts to successfully restore life in cardiac arrest victims are formidably challenging. They require not only that cardiac activity be initially reestablished but that injury to vital organs be prevented or minimized. In this article, we discuss the effects that cardiac arrest and resuscitation have on the myocardium, describing first the functional myocardial abnormalities that occur during cardiac resuscitation, which may limit the ability to reestablish cardiac activity. We then discuss strategies for minimizing myocardial injury and examine novel therapies aimed at minimizing ischemia and reperfusion injury. Finally, we discuss sodium-hydrogen exchanger isoform-1(NHE-1) inhibitors and erythropoietin for maintaining myocardial function during cardiopulmonary resuscitation.

Keywords

myocardial ischemic injury; reperfusion myocardial injury; cardiopulmonary resuscitation; NHE-1 inhibitors; erythropoietin

Hrčak ID:

59927

URI

https://hrcak.srce.hr/59927

Publication date:

1.10.2010.

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