Original scientific paper

Determination of the Lipophilicity of Some New Derivatives of Thiosemicarbazide and 1,2,4-triazoline-5-thione with Potential Antituberculosis Activity

Monika Pitucha ; Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, Staszica 6, 20-081 Lublin, Poland
Beata Polak ; Department of Physical Chemistry, Chair of Chemistry, Faculty of Pharmacy, Medical University of Lublin, Staszica 6, 20-081 Lublin, Poland
Marta Swatko-Ossor ; Department of Biochemistry, Faculty of Pharmacy, Medical University of Lublin, Chodźki 1, 20-093 Lublin, Poland
Łukasz Popiołek ; Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, Staszica 6, 20-081 Lublin, Poland
Grażyna Ginalska ; Department of Biochemistry, Faculty of Pharmacy, Medical University of Lublin, Chodźki 1, 20-093 Lublin, Poland

Abstract

The chromatographic behavior of newly obtained derivatives of thiosemicarbazide and 1,2,4-
triazoline-5-thione was determined. The lipophilicity was confirmed by the use of the Reversed Phase
Thin-Layer Chromatography (RP-TLC) method. For both groups of solutes the lipophilicity depended on
the substituents. All obtained compounds were tested for their antimycotic activity. The strongest antituberculosis
activity was observed for 4-(2-iodophenyl)-1-(pyridine-4-ylacetyl)thiosemicarbazide 4 and 4-
phenyl-3-(pyridine-4-ylmethyl)-1,2,4-triazoline-5-thione 27.

Keywords

thiosemicarbazide; 1; 2; 4-triazoline-5-thione; Mycobacterium tuberculosis; lipophilicity

Hrčak ID:

62207

URI

https://hrcak.srce.hr/62207

Publication date:

5.10.2010.

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