Review article

Immunobiology of renal transplantation

Zlatko Trobonjača orcid.org/0000-0001-7548-5717 ; Zavod za fiziologiju i imunologiju, Medicinski fakultet Sveučilišta u Rijeci
Stela Živčić-Ćosić orcid.org/0000-0002-0770-8808 ; Zavod za nefrologiju i dijalizu, Klinika za internu medicinu, Klinički bolnički centar Rijeka
Jasna Lisjak ; Zavod za nefrologiju i dijalizu, Klinika za internu medicinu, Klinički bolnički centar Rijeka

Abstract

Renal transplants are usually received from geneically non-identical donors, which
induces the recipient’s immune system to develop a transplantation reaction. This reaction
is primarily directed against foreign MHC molecules, but also to other incompatible strong
and weak tissue antigens. The intensity of the immune response depends on donor-dependent
factors, primarily the expression of incompatible HLA antigens and the presence of
antigen presenting cells in the allograft. Among recipient’s factors, the most important is an
earlier sensitation and development of antibodies against AB0 and HLA antigens. In this paper
we summarize the recent knowledge on clinical features and basic immune mechanisms
of the transplantation reaction, which represents the basis for imunosuppressive treatment
for renal transplantation.

Keywords

immunobiology of transplantation; kidney transplantation; MHC; transplantation reaction

Hrčak ID:

63065

URI

https://hrcak.srce.hr/63065

Publication date:

8.12.2010.

Article data in other languages: croatian

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