Review article
S-Adenosylhomocysteine Hydrolase (AHCY) Deficiency: A Natural Model System for Methylation Research
Robert Belužić
; Ruđer Bošković Institute, Division of molecular medicine, Zagreb, Croatia
Oliver Vugrek
orcid.org/0000-0002-8482-8889
; Ruđer Bošković Institute, Division of molecular medicine, Zagreb, Croatia
Abstract
AHCY deficiency is a new human methylation disorder, discovered recently in Croatia, and a natural model for investigating processes related to the methylome. Methylation plays an important role in regulating biological processes and is crucial for gene expression, imprinting, signalling, protein synthesis and lipid metabolism. Thus, methylation has broad impact and provides a suitable base for interdisciplinary research. Linking genomics, proteomics, cellomics, lipidomics and metabolomics and other omics approaches may create a new research avenue – ‘AHCYdomics’ - a new methylation research platform based on AHCY deficiency. Using such research platform will allow to efficiently explore the full potential of the human methylation disorder AHCY deficiency, and to design methods and approaches that will lead to a better understanding of the human methylome.
Keywords
Methylomics; omics research; methyltransferase; transmethylation; homocysteine; genotype – phenotype
Hrčak ID:
63159
URI
Publication date:
15.12.2010.
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