Professional paper

Molecular analysis of human papillomaviruses: a clinical significance

Adriana Vince ; Klinika za infektivne bolesti "Dr. Fran Mihaljević", Zagreb, Hrvatska
Snježana Židovec-Lepej ; Klinika za infektivne bolesti "Dr. Fran Mihaljević", Zagreb, Hrvatska

Abstract

Human papillomaviruses (HPV) are a heterogeneous group of viruses that have throughout their evolution adapted to replication in epithelial cells. Persistent infection with human papillomaviruses represents a necessary co-factor for the development of benign and malignant epithelial neoplasia. Different oncogenic potential of individual HPV genotypes encouraged numerous studies on clinical significance of the observed molecular heterogeneity of HPV. Molecular analysis of HPV is relevant not only for basic virological research but for human medicine as well with particular emphasis on association between HPV and various types of human tumors, development of clinically validated diagnostic assays, assessment of risk for progression of cervical lesions, vaccine design and development, analysis of pre-vaccination distribution of HPV genotypes, analysis of vaccine coverage and efficacy as well as monitoring of possible genotype replacement following introduction of universal HPV vaccination.

Keywords

HPV; molecular methods; cervical carcinoma

Hrčak ID:

63717

URI

https://hrcak.srce.hr/63717

Publication date:

30.9.2010.

Article data in other languages: croatian

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