Original scientific paper
Impaired Cerebral Vasoreactivity in Type 2 Diabetes Mellitus
Vladimira Vuletić
Ljiljana Čengić
Silvio Bašić
Davor Sporiš
Dario Rahelić
Vida Demarin
Abstract
The aim of our study was to assess cerebral vasoreactivity (CVR) in type 2 diabetes mellitus (DM2) and factors which
may influence on it. According to previous studies, evaluating CVR in DM2 on the similar way, the results were dubious.
For the evaluation CVR we used breath holding index (BHI) and transcranial Doppler ultrasound (TCD) in 50 patients
with DM2 and 50 sex- and age-matched healthy controls. We observed epidemiologic and clinic data, other vascular risk
factors and laboratory parameters. We found statistically significant difference in BHI between patients with DM2
(BHI=0.69±0.31) and age- and sex- matched healthy controls (BHI=1.33±0.28) (p<0.05). Because of a significant correlation
between BHI and age (p<0.001) in healthy controls we made an adjustment of BHI for age before further analyses
(BHIadj). In DM2 group we found a significant correlation between BHIadj and age (p=0.0004), fasting glycemia (p=
0.04), and albuminuria (p=0.04) (creatinine clearance in multivariate analysis (p=0.007)). Our study has shown that
CVR is impaired in DM2 patients and that it’s severity was associated with age, fasting glycemia and renal function.
Functional TCD is a very good screening method for detection and monitoring of cerebral microangiopathic changes in
DM2 patients.
Keywords
type II diabetes mellitus; Breath-holding index (BHI); cerebral vasoreactivity
Hrčak ID:
64726
URI
Publication date:
7.3.2011.
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