Original scientific paper

ICTP in Bone Metastases of Lung Cancer

Ana Franjević
Radomir Pavićević
Gordana Bubanović

Abstract

Bone metastases often appear in advanced stages of lung cancer. They are the result of modulation of bone metabolism
by tumor cells that migrated into bone microenvironment and degraded bone organic matrix. Measurement of C-terminal
telopeptide of type I collagen (ICTP) in the serum of subjects with lung cancer with and without bone metastases and
healthy population is the way to explore bone resorption. In 343 subjects included in this research ICTP level was significantly
higher in the bone metastasis than other two groups. The existence of pathologic fracture significantly increased
ICTP level. ICTP showed sensitivity of 66.0% in bone metastases at 95.0% specificity in lung cancer stages IA and IB.
ICTP is a good diagnostic marker in detection of bone metastasis of lung cancer. Its level can distinguish lung cancer
with and without bone involvement and can be used as an addition to standard techniques used in diagnostics of bone
metastasis.

Keywords

bone matrix; lung neoplasms; osteoclasts; osteolysis

Hrčak ID:

64730

URI

https://hrcak.srce.hr/64730

Publication date:

7.3.2011.

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