Original scientific paper
The Etiological Relation between Serum Iron Level and Infection Incidence in Hemodialysis Uremic Patients
Gordan Galić
Monika Tomić
Krešimir Galešić
Ante Kvesić
Martina Šoljić
Zdravka Lončar
Maksim Valenčić
Željko Martinović
Šime Vučkov
Abstract
Through the treatment of anaemia in dialysis patients part of the iron ions remain free in the serum which is at the
bacterias disposal for growth and the strengthening of their virulence. The linear relation of the increased serum iron
level and tissue iron stores in the body and the infection incidence in dialysed patients has become more emphasised. The
need of a clearly defined upper threshold of the serum iron concentration limit has been mentioned in scientific journals
intensely, and consequently the demand for more precise professional instructions for anaemia treatment. For the purpose
of participating in these professional and scientific discussions, we have observed the relation between the iron overload
of the organism and complication incidence in 120 of our haemodialysis uremic patients, with special emphasis on
infections. It has been established that the sepses incidence is much higher in patients with a serum ferritin concentration
above 500 mg/L, than in those patients with a ferritin level lower than the mentioned value (c
2=7.857, p=0.005). The
incidence of vascular access infection is significantly higher in those patients with a serum ferritin level above 500 mg/L
than in those patients with a ferritin level lower than the mentioned value (c
2=23.186, p=0.001). Furthermore, it has
been determined that the incidence of total infection in patients is 3.8 episodes per 100 patients months, which is in accordance
to the referral values of other authors. Conclusion – In the analysis of the achieved results, it has been determined
that the infection incidence is significantly higher in dialysed patients with a serum iron level higher than 500 g/L, than
in those patients with lower values.
Keywords
chronic renal failure; hemodialysis; iron overload; infection
Hrčak ID:
64749
URI
Publication date:
7.3.2011.
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