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Successful Use of Recombinant Factor VIIa in Traumatic Liver Injury – A Case Report
Senka Baranović
Ivan Zvonimir Lubina
Tatjana Nikolić
Branka Maldini
Abstract
The paper describe the use of rFVIIa in the management of massive bleeding in a patient with polytrauma involving
liver injury. An 18-year-old girl with severe polytrauma sustained during a bus–car collision. She had multiple musculoskeletal
injuries, severe concussion of the liver with amputation of the left liver lobe, disruption of the left hepatic
vein from the inferior vena cava, and impaired hemostasis. Acute bleeding (>5 L) was not improved by conservative
methods and a single dose of rFVIIa 90 g/kg was administered. Infusion of rFVIIa resulted in an immediate clinical effect
with rapid improvements in blood laboratory measurements and coagulation parameters. rFVIIa should be considered
as an adjunctive treatment for the control of hemorrhage in severely injured patients with uncontrolled bleeding
and impaired hemostasis.
Keywords
recombinant FVIIa; polytrauma; liver; coagulopathy; hemorrhage; hemostasis
Hrčak ID:
64783
URI
Publication date:
7.3.2011.
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