Review article

Pleiotropic Effects of Statins

Damir Fabijanić ; KBC Split

Abstract

Recent clinical studies suggest that the beneficial effects of statins on cardiovascular risk may not only be due to their cholesterol lowering effects, but also to their cholesterol- independent – pleiotropic – effects. These effects include improvement of endothelial function, attenuating vascular and myocardial remodeling, inhibiting vascular inflammatory response, and stabilizing atherosclerotic plaques, mechanisms which are important in chronic process of atherogenesis, and are particularly pronounced in emerging acute cardiovascular events. This review presents statins pleiotropism through results of basic and clinical studies, with special emphasis on the importance of pleiotropic effects in patients with acute coronary syndrome and in high risk patients with stable coronary artery disease.

Keywords

atherosclerosis; coronary artery disease; acute coronary syndrome; statins; pleiotropism

Hrčak ID:

65099

URI

https://hrcak.srce.hr/65099

Publication date:

11.12.2010.

Article data in other languages: croatian

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