Review article

Antiaggregational Therapy

Mijo Bergovec ; KB Dubrava
Hrvoje Vražić ; KB Dubrava

Abstract

Pathophysiological explanation of the antiplatelet therapy importance lies in the central role of platelets in atherothrombotic disease, which is in the very foundations of both acute and chronic coronary artery disease, peripheral arterial disease and cerebral arteries disease. Today, many medications are available that change the properties of platelets using different mechanisms. Numerous clinical trials have demonstrated the effectiveness of antiplatelet therapy in various atherothrombotic diseases, although some questions still remain unanswered. This review of antiplatelet therapy will briefly describe current knowledge about acetylsalicylic acid, thienopyridines (ticlopidine, clopidogrel, prasugrel, ticagrelor), glycoprotein IIb/IIIa receptor antagonists and the combination treatment.

Keywords

antiaggregational therapy; acetylsalicylic acid; thienopyridines; ticlopidine; clopidogrel; prasugrel; ticagrelor; glycoprotein IIb/IIIa receptor antagonists; combination treatment; acute coronary syndrome

Hrčak ID:

65105

URI

https://hrcak.srce.hr/65105

Publication date:

11.12.2010.

Article data in other languages: croatian

Visits: 8.932 *