Original scientific paper

RECENT ADVANCES IN DIAGNOSIS, MANAGEMENT AND PREVENTION OF RH IMMUNISATION

Ratko Matijević orcid.org/0000-0003-1693-7474 ; Klinika za ginekologiju i porodništvo Opće bolnice Sveti Duh, Sveti Duh 64, Zagreb
Mario Knežević ; Klinika za ginekologiju i porodništvo Opće bolnice Sveti Duh, Sveti Duh 64, Zagreb

Abstract

Rh immunization and hemolytic disease of the fetus and newborn (HDFN) are one of the most common causes of fetal anemia in pregnancy. Traditionally used amniocentesis and determination of OD 450 using Liley diagram is nowadays replaced by measurements of the peak systolic velocity of the blood flow in the middle fetal cerebral artery. Further advances are obtained in the treatment of HDFN where conservative treatment is completely replaced by intrauterine intravascular blood transfusion. As well as that, there is a marked improvement obtained by adapting the prophylactic protocol, with the most important, administration of anti D immunoglobulin to all Rh negative women. These three procedures resulted in reduction of perinatal mortality and morbidity related to HDFN.

Keywords

Rh immunization; diagnosis; Doppler; fetal anemia; intrauterine intravascular transfusion; prevention

Hrčak ID:

65717

URI

https://hrcak.srce.hr/65717

Publication date:

1.6.2009.

Article data in other languages: croatian

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