Professional paper
THE ROLE OF IgG AVIDITY IN DIAGNOSTICS OF CYTOMEGALOVIRUS INFECTION DURING PREGNANCY
Nataša Beader
; Klinički bolnički centar u Zagrebu; Klinički zavod za kliničku i molekularnu mikrobiologiju, Kišpatićeva 12, 10 000 Zagreb
Snježana Škrablin-Kučić
; Odjel za patologiju trudnoće, Klinika za ženske bolesti i porode
Slobodan Mihaljević
; Odjel za anesteziologiju i intenzivno liječenje
Zoran Veir
; Klinika za kirurgiju, KBC zagreb
Abstract
. Objective. Cytomegalovirus (CMV) is one of the leading causes of mental retardation and other neurological defects in infants. To date, there is no commonly accepted algorithm for detection of intrauterine HCMV infections during pregnancy and neonatal period. Primary CMV infections during gestation present a 40% risk of intrauterine transmission in contrast to nonprimary infections. In this small study, we decided to identify pregnant women with primary CMV infection with IgG avidity test. Material and methods. The study included 33 pregnant women whose sera were tested to CMV IgM, IgG antibodies and IgG avidity. All the blood samples were tested with antigenemia CMV pp65 test. Results. 3 (9%) pregnant women were CMV seronegative and 30 (91%) were CMV seropositive. Low IgG avidity index (AI) was detected in 1 (3%), intermediate in 3 (9%) and high AI in 26 (79%) pregnant women. CMV IgM antibodies with intermediate IgG AI were detected in 5 (15%) pregnant women. All the blood samples tested with antigenemia CMV pp65 test were negative. Conclusion. IgG avidity test differentiates primary from nonprimary CMV infection in pregnant women.
Keywords
cytomegalovirus; pregnancy; intrauterine infections; CMV IgG avidity
Hrčak ID:
65960
URI
Publication date:
1.9.2009.
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