Original scientific paper
Interleukine-8, monocyte chemotactic protein-1 and interleukine-10 in leptospiral and hantaviral infections
Ljiljana Žmak
; Hrvatski zavod za javno zdravstvo, Zagreb
Alemka Markotić
; Klinika za infektivne bolesti
Ljiljana Mišić-Majerus
; OB "Dr. Tomislav Bardek", Koprivnica
Abstract
Leptospirosis and hemorrhagic fever with renal syndrome (HFRS) are zoonoses distributed worldwide and almost entire Croatia except its islands and seaside is endemic region for these diseases. The aim of our study was to analyze the levels of interleukine-8 (IL-8), monocyte chemotactic protein-1 (MCP-1) and interleukine-10 (IL-10) in patients with acute leptospirosis and to determine the dynamics of their production during the course of the disease. Moreover, we analyzed the levels of these cytokines in patients with acute HFRS and compared them with the levels found in patients with leptospirosis. In comparison to controls, significantly higher production of IL-8 and MCP-1 was found in patients with acute leptospirosis, but the levels were unchanged during the course of the disease. Significantly higher levels of IL-8 and MCP-1 were also found in patients with acute HFRS, however there was no significant difference in the measured cytokine level between patients with HFRS and leptospirosis.
Keywords
hemorrhagic fever with renal syndrome; leptospirosis; cytokines/chemokines; immune response
Hrčak ID:
66667
URI
Publication date:
31.3.2011.
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