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Signa vitae : journal for intesive care and emergency medicine, Vol. 8 No. 2, 2013.

Izvorni znanstveni članak

Leukocytes influence peripheral tissue oxygenation and perfusion in neonates

GERHARD PICHLER ; Department of Paediatrics, Medical University of Graz, Auenbruggerplatz 30, 8036 Graz, Austria
CORINNA BINDER ; Department of Paediatrics, Medical University of Graz, Auenbruggerplatz 30, 8036 Graz, Austria
BERNDT URLESBERGER ; Department of Paediatrics, Medical University of Graz, Auenbruggerplatz 30, 8036 Graz, Austria
NICHOLAS MORRIS ; Department of Paediatrics, Medical University of Graz, Auenbruggerplatz 30, 8036 Graz, Austria
BERNHARD SCHWABERGER ; Department of Paediatrics, Medical University of Graz, Auenbruggerplatz 30, 8036 Graz, Austria
REGINA RIEDL ; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Austria

Puni tekst: engleski pdf 107 Kb

str. 20-23

preuzimanja: 881

citiraj

Sažetak

Background. Leukocyte counts may influence peripheral (micro) circulation due to changes in rheology. The aim of this study was to investigate a possible association between leukocyte counts and peripheral tissue oxygenation/perfusion measured with near infrared spectroscopy (NIRS) in term and preterm neonates. Methods. In this observational study we included term and preterm neonates within the first 2 months of life, in whom peripheral tissue NIRS measurements were performed and blood samples (leukocytes and C reactive protein (CRP)) taken to investigate clinical signs of infection. Tissue-oxygenation index (TOI), fractional oxygen extraction (FTEO), oxygen delivery (DO
2 ), oxygen consumption (VO
TOI, FTOE, DO 2
, VO 2
2 ) and vascular resistance (VR) were measured by NIRS and venous occlusion method.
and VR were correlated to leukocyte counts on the same day and maximal CRP levels within 24 hours (CRP max). Results. In 180 infants, with a mean gestational age of 35.5±3.3 weeks, leukocyte counts were 16546± 8830/l (median 14830; range 1790 to 67840) and CRP max was 8.0± 19.0 mg/l (median 0.0; range 0.0 to 110.0mg/l). TOI was 71.1±5.5%, FTOE 28.5±6.1%, DO
2 46.7±19.7, VO
2 12.5±4.4 and VR 11.7±6.4.
Leukocyte counts correlated negatively (r= -0.21; p= 0.005) with TOI and positively (r=0.17; p=0.029) with VR. Correlations with CRP max did not reach significance. Conclusion. We demonstrated that peripheral tissue oxygen consumption decreases and vascular resistance increases with increasing leukocyte counts.

Ključne riječi

near-infrared spectroscopy; neonate; microcirculation; leukocytes

Hrčak ID:

110164

URI

https://hrcak.srce.hr/110164

Datum izdavanja:

1.10.2013.

Posjeta: 1.789 *