Veterinarski arhiv, Vol. 83 No. 6, 2013.
Izvorni znanstveni članak
Amelioration of chicken infectious anaemia virus induced immunosuppression by immunomodulator and haematinic supplementation in chicks.
Prakash Bhatt
; Veterinary Clinics, College of Veterinary and Animal Sciences, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Udham Singh Nagar, Uttarakhand, India
Santosh K. Shukla
; Department of Clinical Medicine, College of Veterinary and Animal Sciences, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Udham Singh Nagar, Uttarakhand, India
Mohd Yaqoob Wani
; Immunology Section, Indian Veterinary Research Institute (IVRI), Izatnagar, India
Ruchi Tiwari
; Department of Microbiology and Immunology, College of Veterinary Sciences, Pandit Deen Dayal Upadhyaya Veterinary University (DUVASU), Mathura, India
Kuldeep Dhama
orcid.org/0000-0001-7469-4752
; Avian Diseases Section, Division of Pathology, Indian Veterinary Research Institute (IVRI), Izatnagar, India
Sažetak
Nutritional immunomodulation represents a new frontier area of research for achieving rational goals of efficient and healthy livestock production, as continuous genetic selection and intensive productions systems have made the animals highly susceptible to various pathogens. In this study, the amelioration of haematinic and immunomodulator on chicken infectious anemia virus (CIAV) induced immmunosupression was studied, with regard to haematological and immunological parameters. Vaccines against Newcastle disease (ND) and infectious bursal disease (IBD) were used as markers for immunological parameter studies. A total of 80 specific pathogen free (SPF) broiler chicks, negative for CIAV antibodies, were randomly divided into four groups (Group I-IV) and were vaccinated against ND and IBD on days 1 and 12, respectively. All chicks of groups II, II and IV were inoculated with CIAV intramuscularly on day 15 of the study, while group I served as control. The chicks of group III and IV were treated with a haematinic (haemocare) and haematinic (haemocare) + immunomodulator (Immuno care), respectively, in drinking water for the entire study period (28 days). Live body weights, haematological parameters, along with humoral immune response (HIR) were measured at regular intervals. The CIAV infected groups showed a significant decline in cell count of erythrocyte and most leukocyte lineages, reduction in live body weights, and antibody titres against ND and IBD viruses. Theintensity of body weight loss, anaemia, leukopenia and depressed humoral immune responses were less severe in CIAV infected chicks fed with haematenic and immunomodulator supplementation diets. Interestingly, dually treated chicks (group IV) had a significantly higher response than the group treated by haematinic alone . In conclusion, the use of immunomodulator plus haematinic supplementation is suggested for providing better protection compared to haematinic supplementation alone, and the combination can be used for prophylaxis and therapeutic purposes against CIA, an economically important and emerging disease of poultry.
Ključne riječi
chicken infectious anaemia; immunotherapeutic; humoral immune response; immuno-modulators; haematinic
Hrčak ID:
111858
URI
Datum izdavanja:
9.12.2013.
Posjeta: 2.801 *