Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2014.55.514
New classification criteria for systemic lupus erythematosus correlate with disease activity
Felina Anić
; Department of Rheumatology and Clinical Immunology, Division of Internal Medicine, University Hospital Center Rijeka, Rijeka, Croatia
Marta Žuvić-Butorac
; Department of Biotechnology,University of Rijeka, Rijeka, Croatia
Davor Štimac
; Department of Gastroenterology, Division of Internal Medicine, University Hospital Center Rijeka Rijeka, Croatia
Srđan Novak
; Department of Rheumatology and Clinical Immunology, Division of Internal Medicine, University Hospital Center Rijeka, Rijeka, Croatia
Sažetak
Aim To determine the prevalence of American College
of Rheumatology (ACR) and Systemic Lupus International
Collaborating Clinics (SLICC) classification criteria among
systemic lupus erythematosus (SLE) patients; to determine
disease activity and severity; and to investigate the correlation
of classification criteria with disease activity, and of disease
activity and damage index with disease duration.
Methods We performed a cross-sectional study on 110
SLE patients from the Division of Rheumatology and Clinical
Immunology, University Hospital Centre Rijeka, Croatia
in the period from September to December 2013 and determined
disease duration and the total number of ACR
and SLICC classification criteria. Disease activity was assessed
by Systemic Lupus Erythematosus Disease Activity
Index (SLEDAI) index and organ damage by Systemic Lupus
International Collaborating Clinics/American College
of Rheumatology (SLICC/ACR) damage index.
Results The number of SLICC classification criteria met per
patient was significantly higher than the number of ACR
criteria (7 [IQR 6-8] vs 5 [IQR 4-6], P < 0.001). Moderate correlations
were detected between the number of SLICC classification
criteria and disease activity index, both in case
of active (r = 0.48, P = 0.003) and inactive disease (r = 0.43,
P < 0.001). We neither found a correlation between the
number of ACR criteria and disease activity nor between
disease activity and disease duration. However, there was
a good correlation between SLICC/ACR damage index and
disease duration (r = 0.63, P < 0.001).
Conclusion New SLICC classification criteria correlate with
disease activity because they capture more manifestations
also included in the SLEDAI index. Patients with longer disease
duration had a larger damage index score.
Ključne riječi
Hrčak ID:
135105
URI
Datum izdavanja:
15.10.2014.
Posjeta: 2.573 *